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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MDH1
All Species:
58.18
Human Site:
S242
Identified Species:
91.43
UniProt:
P40925
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40925
NP_005908.1
334
36426
S242
I
K
A
R
K
L
S
S
A
M
S
A
A
K
A
Chimpanzee
Pan troglodytes
XP_001163596
334
36422
S242
I
K
A
R
K
L
S
S
A
M
S
A
A
K
A
Rhesus Macaque
Macaca mulatta
XP_001084973
344
37589
S252
I
K
A
R
K
L
S
S
A
M
S
A
A
K
A
Dog
Lupus familis
XP_531844
334
36408
S242
I
K
A
R
K
L
S
S
A
M
S
A
A
K
A
Cat
Felis silvestris
Mouse
Mus musculus
P14152
334
36493
S242
I
K
A
R
K
L
S
S
A
M
S
A
A
K
A
Rat
Rattus norvegicus
O88989
334
36465
S242
I
K
A
R
K
L
S
S
A
M
S
A
A
K
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511259
334
36411
S242
I
K
A
R
K
L
S
S
A
M
S
A
A
K
A
Chicken
Gallus gallus
Q5ZME2
334
36525
S242
I
K
A
R
K
L
S
S
A
M
S
A
A
K
A
Frog
Xenopus laevis
Q6PAB3
334
36407
S242
I
K
A
R
K
L
S
S
A
M
S
A
A
K
A
Zebra Danio
Brachydanio rerio
NP_956263
333
36201
S242
I
K
A
R
K
L
S
S
A
M
S
A
A
K
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609394
337
36040
S242
I
A
A
R
K
M
S
S
A
M
S
A
A
K
A
Honey Bee
Apis mellifera
XP_394487
333
36140
S242
I
A
A
R
K
M
S
S
A
M
S
A
A
K
A
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796283
335
36178
S242
I
K
A
R
K
L
S
S
A
M
S
A
A
K
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q08062
332
35571
S242
I
I
K
A
R
K
F
S
S
A
L
S
A
A
S
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P93819
332
35552
S242
I
I
K
A
R
K
L
S
S
A
L
S
A
A
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96.2
95.2
N.A.
96.4
97
N.A.
91.6
90.4
86.8
78.7
N.A.
65.8
63.4
N.A.
68.3
Protein Similarity:
100
100
96.8
98.1
N.A.
99.4
99.6
N.A.
97.5
96.7
94
89.8
N.A.
77.4
77.2
N.A.
82
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
86.6
86.6
N.A.
100
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
93.3
93.3
N.A.
100
Percent
Protein Identity:
N.A.
61
N.A.
61.6
N.A.
N.A.
Protein Similarity:
N.A.
73.9
N.A.
75.4
N.A.
N.A.
P-Site Identity:
N.A.
20
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
46.6
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
14
87
14
0
0
0
0
87
14
0
87
100
14
87
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
100
14
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
74
14
0
87
14
0
0
0
0
0
0
0
87
0
% K
% Leu:
0
0
0
0
0
74
7
0
0
0
14
0
0
0
0
% L
% Met:
0
0
0
0
0
14
0
0
0
87
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
87
14
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
87
100
14
0
87
14
0
0
14
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _